RNA, U1 small nuclear 6, pseudogene (RNU1-6P)

RNA, U1 small nuclear 6, pseudogene (RNU1-6P) is classified as a non-protein-coding RNA pseudogene in the human genome[1]. It is a member of a large family of U1 small nuclear RNA (snRNA) pseudogenes, which are sequences resembling genuine U1 snRNA genes but typically have sequence variations (mutations, deletions, or insertions) that render them unable to encode functional RNA or protein products[1][2]. While canonical U1 snRNA genes play crucial roles in mRNA splicing as core spliceosome components[4], most pseudogenes—including RNU1-6P—are generally thought to lack biological activity[1][2]. Some U1 snRNA pseudogenes can give rise to variant small nuclear RNAs with regulatory functions, but direct evidence for biological function of RNU1-6P specifically is lacking[2][3]. RNU1-6P is not considered a therapeutic target, does not encode a receptor, enzyme, or other druggable protein, and has no direct involvement in disease or clinical decision-making[1][2]. Key interpretation note: Because RNU1-6P is a non-functional pseudogene and not an active protein or functional regulatory RNA, it is not considered a valid therapeutic target. The entry is essentially incorrect as a therapeutic target. Key details from sources: - It is a pseudogene and not a functional U1 snRNA[1][2]. - U1 snRNA itself is critical to splicing and can have variant forms with identifiable functions, but RNU1-6P specifically has no documented function or clinical significance[2][3]. If a true U1 snRNA variant or functional family member is needed, consult canonical U1 snRNA (RNU1-1 or related), which is integral to pre-mRNA splicing and other RNA processing[2][3][4].

Other names

RNU1-6PRNU1-6