RNA, U1 small nuclear 93, pseudogene (RNU1-93P)

RNU1-93P, or RNA, U1 small nuclear 93, pseudogene, is a genomic sequence that resembles the coding region for U1 small nuclear RNA but has accumulated differences (base changes, deletions, insertions) that disrupt its ability to encode a canonical U1 snRNA molecule. U1 snRNA and its variant forms are essential components of the spliceosome—the complex responsible for accurate removal of introns from pre-mRNA transcripts. Variant U1 snRNAs generated from pseudogenes can be transcribed and processed, associating with spliceosomal complexes in vivo, and have been implicated in the regulation of mRNA processing and in some cell-type-specific regulatory functions. However, RNU1-93P itself is a pseudogene and is not considered a classic receptor, enzyme, or other canonical therapeutic/protein target. Its role in disease and as a therapeutic target is unestablished. The submitted aliases (HTR2B, PSMD1, TSARG1) are incorrect and unrelated. Key issues include: RNU1-93P is a pseudogene for U1 snRNA, not a receptor, enzyme, or classic therapeutic target. The alternate names HTR2B, PSMD1, TSARG1 are incorrect; they correspond to entirely different proteins/genes. No drugs act on this target, and no established biomarker or disease role exists for RNU1-93P. It is recommended to use RNU1-93P as the canonical term, with proper molecular classification as a small nuclear RNA pseudogene; remove the other aliases.

Other names

Variant U1 snRNA pseudogeneU1 snRNA class I pseudogene

Not applicable. No drugs are known to target RNU1-93P.