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RNA, U11 small nuclear (U11 snRNA)
- Target
- U11 snRNA
- Molecular classification
- Small nuclear RNA (snRNA), Non-coding RNA, Component of minor spliceosomal complex
01
Overview
RNA, U11 small nuclear (U11 snRNA) is a highly conserved, non-coding small nuclear RNA that is an essential component of the minor spliceosome complex. It recognizes and binds to the 5' splice site of U12-type pre-mRNA introns, facilitating alternative splicing. U11 snRNA forms a bicomplex with U12 snRNA—together, they bridge intron ends in pre-spliceosomal complexes, enabling the removal of specific introns during pre-mRNA processing. This unique splicing pathway is critical for generating proteomic diversity and regulating gene expression. While not a traditional therapeutic target, U11 snRNA has been associated with rare genetic diseases and may have immunomodulatory functions due to its sequence characteristics
- Other names
- RNU11U11 snRNARNA, U11 small nuclearENSG00000274978
02
Biological functions
mRNA 5'-splice site recognitionRNA splicing (minor spliceosomal pathway)Alternative splicing regulationFormation of U11/U12 di-snRNP complex
03
Disease associations
Association with autoimmune diseases (high serum levels)In rare cases, can act as a Mendelian disease gene (recessive)Esophageal leukoplakiaMicrocephalic osteodysplastic primordial dwarfism, type I
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