RNA, U2 small nuclear 2 (RNU2-2)

RNA, U2 small nuclear 2 (RNU2-2) encodes a small nuclear RNA (snRNA) that is an essential RNA component of the spliceosome, the molecular machinery responsible for removing introns from precursor messenger RNA (pre-mRNA) in eukaryotes[1][4][7]. RNU2-2 is one of several gene loci encoding U2 snRNA in humans; unlike RNU2-1, RNU2-2 maps uniquely to chromosome 11 and was previously annotated as a pseudogene but is now known to be expressed and stably incorporated into the spliceosome[2][11][14]. U2 snRNA interacts with the intronic branch site and other snRNAs (notably U6) and critical proteins to orchestrate intron recognition and catalysis during splicing[1][4][7]. Mutations in RNU2-2 have been implicated in severe neurodevelopmental disorders with epilepsy, and recurrent somatic mutations affect multiple cancer types[2][8][11]. U2 snRNA is not a traditional drug target like receptors or enzymes but is a pivotal noncoding RNA, and its misregulation or mutation has clear disease implications[2][8][11]. No direct drug interactions are known, and it is excluded from standard target classes such as enzyme or receptor, falling instead under "Other" as a noncoding RNA and core spliceosomal component[1][4][7][14].

Other names

U2U2 small nuclear RNA 2U2 snRNA 2U2-2RNU2-2P (historic/pseudogene annotation)U2 spliceosomal RNA