RNA, U2 small nuclear 30, pseudogene (RNU2-30P)

RNU2-30P is a pseudogene of the U2 small nuclear RNA in humans[1]. U2 small nuclear RNA (snRNA) is a component of the U2 small nuclear ribonucleoprotein (snRNP), which is an essential part of the spliceosome responsible for pre-mRNA splicing in eukaryotic cells[2]. However, as a pseudogene, RNU2-30P does not encode a functional U2 snRNA and is not known to have a direct biological function, disease association, or therapeutic relevance[1]. It primarily serves as a non-functional, transcriptionally inactive genomic sequence that shares sequence similarity with active U2 snRNA genes. ### Additional context - U2 snRNA plays an essential role in mRNA splicing (removal of introns from pre-mRNA) by base-pairing with the branch point of the intron during the formation of the spliceosome[2], but RNU2-30P is simply a non-functional copy—i.e., a pseudogene—within the human genome[1]. - While the main U2 snRNA (e.g., RNU2-1, RNU2-2) has clear biological functions, pseudogenes like RNU2-30P typically do not produce active RNAs or proteins, are not used as drug targets, and lack clinical or biomarker roles[1]. - There is no evidence RNU2-30P is implicated in any disease, interacts with drugs, serves as a biomarker, or poses therapeutic safety concerns. Summary: RNU2-30P is a pseudogene of the U2 small nuclear RNA and is not considered a therapeutically relevant target, functional gene, or molecular entity of direct biological significance in current biomedical research[1].

Other names

RNU2-30P