RNA, U4 small nuclear 25, pseudogene (RNU4-25P)

RNU4-25P (RNA, U4 small nuclear 25, pseudogene) is annotated as a **pseudogene** of the small nuclear RNA (snRNA) family in humans[1][2]. As a pseudogene, it does not produce a functional RNA or protein product and is not considered active in canonical molecular or disease processes. Functional U4 small nuclear RNA genes (e.g., RNU4-2) are essential components of the major spliceosome complex and play a critical role in pre-mRNA splicing, but RNU4-25P itself does not encode a functional snRNA and thus does not perform these biological functions. No known therapeutic drugs target RNU4-25P, and it is not classed as a druggable target, biomarker, or safety concern for any disease[1][2]. **Summary of core issues:** - RNU4-25P is a **non-functional snRNA pseudogene** — not a receptor, enzyme, transporter, or known drug target[1][2]. - The functional gene family member is RNU4-2 (U4 snRNA), not RNU4-25P[3][4][5]. - No biological, therapeutic, or diagnostic role attributed to RNU4-25P in current research databases[1][2]. - The gene is correctly identified and named; the issue is that it is not a genuine molecular target. **Note on ambiguity:** There is confusion in the literature between **functional U4 snRNA genes** (e.g., RNU4-2, which are linked to neurodevelopmental disease when mutated[3][4][5]) and numerous *pseudogenes* like RNU4-25P, which are noncoding and non-functional. For disease roles, spliceosomal snRNA variants do play critical roles (such as in ReNU syndrome), but this *does not apply* to RNU4-25P specifically[3][4][5].

Other names

RNU4-25PRNA, U4 small nuclear 25, pseudogene