RNA, U4 small nuclear 78, pseudogene (RNU4-78P)

RNU4-78P represents a pseudogene of the U4 small nuclear RNA gene family in Homo sapiens[1][5]. Pseudogenes are genomic DNA sequences similar to normal genes but are typically non-functional due to mutations, deletions, or truncations that prevent their expression or function[5]. RNU4-78P is similar in sequence to the U4 small nuclear RNA (snRNA), a component of the spliceosome crucial for pre-mRNA splicing, but it is not known to encode a functional RNA product or contribute directly to splicing activity[1][5]. As a pseudogene, RNU4-78P is not considered a therapeutic target, does not have a known biological function, disease association, or interacting drugs, and is generally used as a genomic reference or for studies of gene evolution[1][5]. There is nothing to suggest active involvement in disease biology, nor any clinical biomarker or safety concern. Although the functional U4 snRNA gene (e.g., RNU4-2) is implicated in neurodevelopmental disorders and the spliceosome, RNU4-78P is a pseudogene—non-functional and not a valid therapeutic or research target[1][3][5]. The only information available relates to its sequence similarity and genomic presence[1][5]. RNU4-78P should not be confused with the active RNU4-2 gene or other U4 snRNA family members involved in splicing and disease[2][3][7].

Other names

RNU4-78P