RNA, U6 small nuclear 131, pseudogene (RNU6-131P)

RNU6-131P is a **pseudogene**, meaning it is a genomic DNA sequence similar to the functional U6 small nuclear RNA (snRNA) genes but is typically non-functional or not expressed as a mature RNA product. The functional **U6 small nuclear RNA** is a critical non-coding RNA component of the spliceosome, where it plays a central role in the excision of introns from pre-mRNA during RNA splicing in eukaryotic nuclei[1][2][3]. Functional U6 snRNA forms extensive secondary structures and interacts with other small nuclear RNAs and proteins to facilitate spliceosome assembly and catalysis of splicing[1][2][3]. However, RNU6-131P, as a pseudogene, does not encode an active snRNA and does not have a defined biological function or recognized disease association. **Clarification of status**: - The designation *pseudogene* means **RNU6-131P is not a therapeutic target**, not a functional receptor, enzyme, transporter, transcription factor, or any druggable biomolecule. - Its primary relevance is as a remnant of evolutionary gene duplication or retroposition, and pseudogene copies of U6 are common in mammalian genomes[2]. - No drugs, disease roles, or biomarker information are associated with RNU6-131P.

Other names

RNU6-131PRNA, U6 small nuclear 131 pseudogene