RNA, U6 small nuclear 135, pseudogene (RNU6-135P)

RNU6-135P is a **non-functional genomic copy** or processed pseudogene, derived from the U6 small nuclear RNA (snRNA), which plays a crucial role in the spliceosome's catalysis of pre-mRNA splicing[1][3]. Pseudogenes such as RNU6-135P are created by *retrotransposition*—a process in which RNA is reverse-transcribed and inserted into the genome[5]. These pseudogenes are typically marked by sequence similarity to their ancestral gene, scrambled sequence features, and lack of regulatory regions needed for transcription. Their presence in the genome is most often considered vestigial, without active biological function[4][5]. The parent U6 snRNA is highly conserved and essential, but its pseudogenes—including RNU6-135P—do not perform its canonical roles and are not considered active molecules or therapuetic targets[3][5]. Key clarifications: - The "RNA, U6 small nuclear 135, pseudogene" is not a receptor, enzyme, channel, transporter, transcription factor, nor any protein; it is a non-coding, non-functional processed pseudogene. - There is no evidence that RNU6-135P is a direct drug target, used as a biomarker, or implicated in disease. - The canonical name and abbreviation as given are already scientifically standard. - Its status as a pseudogene means it is not a meaningful molecular target in biomedical research or clinical therapy contexts.

Other names

RNU6-135PRNA, U6 small nuclear 135, pseudogene