RNA, U6 small nuclear 28, pseudogene (RNU6-28P)

RNU6-28P (RNA, U6 small nuclear 28, pseudogene) is a genomic sequence classified as a pseudogene, derived from duplication or retrotransposition of the U6 small nuclear RNA gene[1][5]. It does not produce a functional RNA or protein and is not involved in splicing or cellular signaling. Pseudogenes such as RNU6-28P serve primarily as genomic fossils without active cellular or disease roles. The functional ancestral U6 snRNA is deeply conserved among eukaryotes and is indispensable for catalyzing pre-mRNA splicing in the nucleus[5][3]; however, RNU6-28P lacks the appropriate regulatory structures and is non-functional. Its presence reflects evolutionary duplications, frequently observed in the non-coding RNA gene families of vertebrate genomes[5]. There are no known disease associations, therapeutic utilities, or biomarker roles for RNU6-28P. If you are seeking information on active therapeutic targets, this pseudogene should be excluded from target or biomarker lists, and attention should be focused instead on functional U6 snRNA or other small nuclear RNAs with proven biological activity[2][3][5].

Other names

RNU6-28RNU6-28PRNA, U6 small nuclear 28, pseudogeneU6-28 pseudogene

Not applicable; pseudogenes do not encode active products. Parent U6 snRNA is involved in RNA splicing; pseudogene has no mechanism or drug targeting.