RNA, U6 small nuclear 340, pseudogene (RNU6-340P)

"RNA, U6 small nuclear 340, pseudogene" (RNU6-340P) is a **pseudogene derived from the U6 small nuclear RNA (snRNA)** gene family. U6 snRNA is an essential, highly conserved noncoding RNA component of the spliceosome, the major nuclear complex responsible for excising introns during pre-mRNA splicing in eukaryotes[3][1]. However, as a **pseudogene**, RNU6-340P is a **non-functional, duplicated genomic copy** of the parental U6 gene that has lost the ability to code for a functional RNA molecule due to accumulated mutations or truncations[2][5]. Such snRNA pseudogenes are common in vertebrate genomes, often generated by **retrotransposition mechanisms** (such as LINE-1-mediated events) and reflect the evolutionary mobility of small nuclear RNA genes[2]. Pseudogenes like RNU6-340P are not known to act as enzymes, receptors, or active molecular targets, nor are they directly involved in disease processes or targeted by drugs[2][3]. **Key points:** - This entry is a **pseudogene**, not an active gene or molecular target. - It does not encode a protein, enzyme, receptor, or regulatory RNA product[2][3][5]. - No known biological functions, disease roles, or drug interactions are associated with this pseudogene. - Its nomenclature "340" refers to its annotation as the 340th U6 pseudogene in the human genome. **Notable issues:** - This is not a valid therapeutic target; it is a **non-functional genomic element**. - Entries for functional spliceosome-related U6 snRNA should instead refer to the canonical "U6 small nuclear RNA" (RNU6-1 or RNU6), which is essential for splicing, but not this pseudogene[1][3].

Other names

RNU6-340PU6 pseudogene 340RNA, U6 small nuclear 340 pseudogene