RNA, U6 small nuclear 345, pseudogene (RNU6-345P)

RNA, U6 small nuclear 345, pseudogene (RNU6-345P) is a **non-coding RNA pseudogene**, representing a genomic sequence that resembles the U6 small nuclear RNA (snRNA) gene but is considered nonfunctional in terms of encoding the canonical U6 snRNA product[5][6]. U6 snRNA itself is a vital component of the spliceosome, essential for pre-mRNA splicing in eukaryotes, and is one of the most highly conserved snRNAs, underscoring its fundamental role in gene expression[3][1]. However, RNU6-345P lacks critical sequence elements or context necessary for this function and is therefore rendered a **pseudogene**[5][6]. Pseudogenes like RNU6-345P can be transcriptionally active and may produce non-coding RNAs that could have regulatory effects—such as acting as *competing endogenous RNAs* (ceRNAs) or *miRNA sponges*—modulating the availability of microRNAs and thus indirectly influencing gene regulation[4]. These roles are often inferred from studies of other pseudogenes in the genome and are not specific or proven for RNU6-345P. There is **no evidence** that RNU6-345P encodes a functional protein, acts as a receptor, enzyme, or transporter, nor is it a therapeutic target, nor does it have direct relevance for drug action, patient biomarkers, or safety concerns. The scientific consensus is that pseudogenes primarily represent genomic relics, though a subset can have regulatory impacts on gene expression[4][5][6]. **In summary**, RNU6-345P is a U6 snRNA-derived pseudogene. It is *not* a canonical therapeutic target, has no established clinical or mechanistic role, and is most accurately classified as a genomic pseudogene with potential non-coding regulatory functions common to its class.

Other names

RNU6-345PU6 snRNA pseudogene 345U6 sRNA pseudogene