RNA, U6 small nuclear 38, pseudogene (RNU6-38P)

**RNA, U6 small nuclear 38, pseudogene** (RNU6-38P) is a non-coding RNA pseudogene in the human genome[1]. It is a member of the U6 small nuclear RNA (snRNA) pseudogene family, which are DNA sequences that closely resemble functional genes but are generally regarded as nonfunctional due to mutations, truncations, or lack of necessary regulatory elements for expression[1]. The functional U6 snRNA is a critical component of the spliceosome, forming part of the U6 small nuclear ribonucleoprotein (snRNP) that is essential for pre-mRNA splicing[6][7]. Pseudogenes like RNU6-38P do not code for functional RNA molecules, are not transcribed or translated into active products, and have no direct biological or disease-related roles[1]. They are not considered therapeutic targets and have no known interactions with drugs, biomarker utility, or associated safety concerns. Their primary significance is genomic, reflecting evolutionary events rather than current biological activity.\n\n**Summary of assessment:**\n- This entry represents a non-coding RNA pseudogene, not a functional gene, protein, enzyme, receptor, or therapeutic target[1].\n- There is nothing functionally unique or actionable about this pseudogene; any biology related to U6 snRNA refers to the functional gene and RNA, not to the pseudogene.\n- Using RNU6-38P as a biomedical \"target\" is incorrect, as pseudogenes are not clinically targeted or researched as receptors, enzymes, or actionable biomolecules[1].\n\n**Alternate names** such as \"RNU6-38P,\" \"RNU6-38,\" and related nomenclature simply refer to this specific pseudogene locus within the larger family of U6 snRNA-related pseudogenes. This is distinct from the functional U6 snRNA gene and its active role in spliceosome-mediated RNA processing[6][7].

Other names

RNU6-38RNU6-38P