RNA, U6 small nuclear 458, pseudogene (RNU6-458P)

RNU6-458P is an annotated human pseudogene, derived from duplication or mutation of the U6 small nuclear RNA (snRNA) gene, a highly conserved non-coding RNA essential for pre-mRNA splicing[2][3]. While canonical U6 snRNA is a critical part of the spliceosome complex, required for catalysis of intron removal from pre-mRNA and involved in the formation of the active site for splicing[1][2], RNU6-458P does not code for a functional RNA and shows features characteristic of pseudogenes, such as nucleotide repeats and sequence divergence[3]. Pseudogenes like RNU6-458P are common in genomes and serve as evidence of evolutionary processes, but they generally lack direct functional, biological, or therapeutic relevance. If you require structured canonical data such as for the true U6 snRNA, which is a core spliceosomal RNA and not a pseudogene (e.g., "U6 small nuclear RNA" or U6 snRNA), that can be provided separately[1][2].

Other names

RNU6-458PRNA, U6-458P pseudogeneU6 snRNA pseudogeneU6 small nuclear RNA pseudogene