Target intelligence / Profile preview

RNA, U6 small nuclear 651, pseudogene (RNU6-651P)

Target
RNU6-651P
Molecular classification
Pseudogene, Small nuclear RNA (snRNA) pseudogene, Long non-coding RNA (lncRNA) pseudogene (by sequence homology)
01

Overview

RNA, U6 small nuclear 651, pseudogene (RNU6-651P) is annotated as a *pseudogene* related to the U6 small nuclear RNA family, which are normally components of the spliceosome essential for pre-mRNA splicing[4]. As a pseudogene, RNU6-651P carries sequence similarity to functional U6 small nuclear RNA genes but contains mutations or structural features that preclude its normal function in splicing. Sequence homology and genomic context indicate that it may produce non-coding transcripts, and, consistent with general pseudogene biology, such sequences can occasionally act as regulators at the RNA level, including acting as competing endogenous RNAs or affecting local chromatin structure, though no functional information exists for this particular gene[3][2][4]. There are no drugs, mechanisms of action, or clinical biomarker roles described for RNU6-651P.

Other names
RNU6-651P
02

Biological functions

Pseudogene loci of snRNAs generally do not encode functional RNAs, but pseudogenes may play a role in regulation of gene expression, such as acting as sources of non-coding RNA transcripts, competing endogenous RNAs (ceRNAs), or miRNA sponges (inferred from general biological roles of pseudogenes; specific function for RNU6-651P is not described in available sources)
03

Disease associations

Other (Evidence for disease association is for specific pseudogenes; as of current knowledge, there is no reported disease association for RNU6-651P itself. Some snRNA pseudogenes have been implicated as modulators of gene regulation in cancer, but no direct evidence for RNU6-651P)

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