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RNA, U6 small nuclear 653, pseudogene (RNU6-653P) is annotated as a pseudogene related to the U6 small nuclear RNA (snRNA) gene family. U6 small nuclear RNA is an essential non-coding RNA component of the spliceosome, directly involved in the catalytic steps of pre-mRNA splicing[3][7]. However, RNU6-653P represents a **pseudogene**—a non-functional genomic sequence derived from duplication or mutation of a functional U6 snRNA gene. Pseudogenes like RNU6-653P typically do not have biological activity, are not transcribed into functional RNAs or proteins, and are not considered therapeutic targets, receptors, enzymes, or transporters[5][3]. There are numerous U6 snRNA-related pseudogenes dispersed in the human genome, reflecting the evolutionary conservation and importance of the parent U6 gene[3][5]. No disease association, drug interaction, biomarker use, or known safety concerns are linked to this pseudogene.
None (not a therapeutic target)
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