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**RNA, U6 small nuclear 657, pseudogene** (RNU6-657P) is a genomic locus classified as a pseudogene related to U6 small nuclear RNA (snRNA), which is a highly conserved non-coding RNA central to the spliceosome complex in eukaryotes[3]. Pseudogenes like RNU6-657P are sequence relatives of functional snRNA genes but are typically non-coding with no known functional RNA product or protein. Many U6-derived pseudogenes are found throughout vertebrate genomes, reflecting the evolutionary importance of the U6 snRNA[3]. While some pseudogenes can exert regulatory functions, there is no specific evidence that RNU6-657P acts as a therapeutic target, disease biomarker, or has a direct role in cellular or disease biology[2][3].
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