RNA, U6 small nuclear 665, pseudogene (RNU6-665P)

RNU6-665P is a *pseudogene*, meaning it is a genomic sequence similar to a genuine gene (in this case, U6 snRNA) but is typically non-functional due to mutations, deletions, or inability to be expressed[2][4][5][6]. U6 snRNA itself is an essential component of the spliceosome, responsible for the excision of introns from pre-mRNA through highly conserved RNA–RNA and RNA–protein interactions in the nucleus[1][3]. However, **RNU6-665P** does not appear to encode a functional RNA molecule and instead is regarded as a relic of a duplication or retrotransposition event in the genome[2][5][6]. Pseudogenes like RNU6-665P are frequent in snRNA gene families, and most are presumed unexpressed and nonfunctional[2][6]. Incorrectness Explanation: RNU6-665P is *not a receptor, enzyme, transporter, or other typical therapeutic target*—it is a *pseudogene*. It also has no documented function, no known disease role, no drug interactions, and is not used as a biomarker in clinical practice. Its mention as a "target" is inaccurate because pseudogenes are classified as nonfunctional genomic elements, unless proven otherwise[2][4][6]. There are no established therapies, mechanisms, or safety concerns relevant to this pseudogene. Additional notes: - The vast majority of snRNA pseudogenes (including RNU6-665P) do not produce functional RNA and are not involved in spliceosome catalysis or any known biological activities[2][4][6]. - True U6 snRNA is highly conserved and essential for splicing, but its pseudogenic copies like RNU6-665P are just genomic fragments with sequence similarity and evolutionary history[3][6].

Other names

RNU6-665PU6 snRNA pseudogene 665