RNA, U6 small nuclear 845, pseudogene (RNU6-845P)

RNU6-845P is a human pseudogene homologous to U6 small nuclear RNA (U6 snRNA), a non-coding RNA crucial for spliceosome function in pre-mRNA splicing[1][3][5]. The U6 snRNA is among the core small nuclear RNAs (snRNAs) that help catalyze intron removal during the maturation of messenger RNA in the nucleus. Pseudogenes like RNU6-845P are considered non-functional copies or derivatives that have lost their ability to produce functional RNA or protein, typically arising from gene duplication or retrotransposition. While some pseudogenes can exert regulatory influences on gene expression, there is no published evidence that RNU6-845P is involved in such functions or is clinically relevant as a disease marker or drug target. Additional notes: - The U6 snRNA itself (not the pseudogene) is highly conserved and essential for splicing, but RNU6-845P does not produce the functional RNA[3][1][5]. - There are many U6 pseudogenes throughout the human genome; most are transcriptionally inactive[5]. In summary: RNU6-845P is a non-functional pseudogene copy of the U6 snRNA gene, not a bona fide therapeutic target, with no recognized role in disease, no known drug interactions, and no safety or biomarker relevance based on current knowledge[3][1][5].

Other names

RNU6-845P

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