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RNA, U6 small nuclear 864, pseudogene (RNU6-864P) is a non-coding RNA pseudogene found in the human genome[2][4][5]. Pseudogenes like RNU6-864P are genomic DNA sequences similar to functional genes but are typically non-transcribed and non-functional due to sequence disruptions or evolutionary mutation[2][6]. This pseudogene derives from the U6 small nuclear RNA (snRNA) gene, which encodes a component of the major spliceosome complex essential for pre-mRNA splicing[1][3]. In contrast to the functional U6 snRNA, RNU6-864P does not encode a protein or functional RNA, does not participate in RNA splicing, and is not therapeutically relevant; it lacks biological activity and is typically unexpressed in healthy tissue[2][4][6]. Pseudogenes can be useful for evolutionary studies but have no known direct role in disease, signaling, or as molecular targets.
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