RNA, U6 small nuclear 940, pseudogene (RNU6-940P)

RNU6-940P is a processed pseudogene sequence derived from the U6 small nuclear RNA gene, part of the snRNA family involved in the spliceosomal excision of introns from pre-mRNA. While the parent U6 snRNA plays a vital role in RNA splicing, its pseudogenes, including RNU6-940P, are relics generated by retrotransposition events—primarily LINE-1 (L1) mediated reverse transcription—and have lost the ability to produce a functional RNA or participate in the spliceosome[4][5][1][3]. Human genomes harbor numerous U6 pseudogenes, likely reflecting historical retrotranspositional events rather than ongoing biological activity[4][5]. Some pseudogenes (not specifically RNU6-940P) can give rise to regulatory RNAs such as siRNAs, which may indirectly influence gene expression, but no evidence specifically implicates RNU6-940P in such a process[6].

Other names

RNU6-940PU6 snRNA pseudogeneU6 snRNA-derived pseudogene