Target intelligence / Profile preview

RNA, U6atac small nuclear 27, pseudogene (RNU6ATAC27P)

Target
RNU6ATAC27P
Molecular classification
Pseudogene, Small nuclear RNA pseudogene, Non-coding RNA
01

Overview

RNA, U6atac small nuclear 27, pseudogene (RNU6ATAC27P) is a processed pseudogene derived from U6atac small nuclear RNA, which is involved in minor spliceosome-mediated splicing of pre-messenger RNA, but the pseudogene itself does not produce a functional snRNA or protein[3][4]. Such pseudogenes are typically products of retrotransposition, displaying sequence homology to functional snRNAs yet lacking canonical gene activity[4]. Some pseudogenes, through their RNA transcripts, can exert regulatory influences by acting as microRNA decoys or sources of endogenous siRNAs, thereby modulating gene expression in trans[1][5]; however, there is no specific evidence or characterization of such functions for RNU6ATAC27P itself[3]. Pseudogenes in general are now recognized for their potential regulatory roles in gene expression, though most are not considered actionable targets in therapeutic development[1][2][5].

Other names
RNU6ATAC27P
02

Biological functions

May participate in the regulation of parental gene expression via RNA-mediated mechanisms (e.g., acting as a microRNA decoy or source of small interfering RNAs)Not known to encode a protein or have classical snRNA-mediated splicing activity
03

Disease associations

No direct association with specific diseases for this specific pseudogene itselfSome snRNA pseudogenes and other pseudogenes modulate cellular processes relevant to cancer and other diseases by regulating their cognate coding genes via microRNA decoy or siRNA generation, but this has not been documented for RNU6ATAC27P

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