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RNA, U7 small nuclear 133 pseudogene (RNU7-133P) is a classified pseudogene in the human genome. Pseudogenes are genomic DNA sequences resembling functional genes but are typically non-functional due to mutations or lack of regulatory elements[2][4]. The original U7 small nuclear RNA (snRNA) is critical in histone mRNA 3' end processing as part of the U7 snRNP complex[1][3], but RNU7-133P does not encode this function. Unlike the functional RNU7-1, which is required for proper histone pre-mRNA processing, RNU7-133P appears as a non-functional copy and has not been demonstrated to produce a transcript with regulatory or coding activity. It is not a therapeutic target, not a receptor, enzyme, transporter, or regulator gene, and currently lacks evidence for involvement in any disease process or drug interaction.
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