RNA, U7 small nuclear 137 pseudogene (RNU7-137P)

**RNA, U7 small nuclear 137 pseudogene (RNU7-137P)** is a human genomic locus annotated as a pseudogene derived from the U7 small nuclear RNA gene family. U7 small nuclear RNAs (snRNAs) are non-coding RNAs that play a critical role in the processing of the 3′ end of replication-dependent histone pre-mRNAs, facilitating correct histone mRNA maturation necessary for DNA replication and cell division. However, this specific locus, RNU7-137P, is classified as a pseudogene, which means it is a non-functional copy or fragment of an ancestral gene and is not known to produce a functional RNA or protein product[1][5]. While U7 snRNA itself is essential for histone pre-mRNA processing[2][5], the pseudogene RNU7-137P does not contribute to this function based on current knowledge and does not have a recognized role in disease, therapeutic targeting, or as a biomarker. **Rationale:** - RNU7-137P is a pseudogene, not known to be transcribed into a functional RNA or involved in any therapeutic, pathophysiological, or pharmacological process[1][5]. - Pseudogenes generally do not produce functional products, and there is no indication from genetic resources or medical literature that this specific pseudogene is expressed or functional in physiology or disease[1][5]. - U7 small nuclear RNA is a true functional molecule with important roles, but RNU7-137P is not an active copy and is not considered a pharmacological or therapeutic target[1][5]. - There are no known drug interactions, disease associations, or described mechanism of action for drugs related to this pseudogene. - "is_incorrect: true" is returned because it is not a functional molecule or drug target; its universal relevance is as a genomic annotation artifact rather than as a biologically or clinically relevant target. **Note:** If you are seeking information about the canonical U7 small nuclear RNA and its function, refer instead to "RNA, U7 small nuclear 1" (RNU7-1), which is expressed and functionally active in histone mRNA 3′ end processing[2][3][5].

Other names

RNU7-137PRNA, U7 small nuclear 137 pseudogene