RNA, U7 small nuclear 47 pseudogene (RNU7-47P)

**RNA, U7 small nuclear 47 pseudogene** (RNU7-47P) is classified as a pseudogene that is related by sequence similarity to functional U7 small nuclear RNA genes but does not code for a functional product[1][6][7]. U7 small nuclear RNA (snRNA) itself is an essential component of the U7 small nuclear ribonucleoprotein (snRNP), required for 3' end processing of replication-dependent histone pre-mRNA[4][5]. However, pseudogenes like RNU7-47P are non-functional genomic sequences that arise from gene duplication or retrotransposition; they do not produce active RNA or protein and lack biological activity or therapeutic relevance[1][6][7]. There is no known direct implication of this pseudogene in disease, no drugs known to target it, and it is not considered a therapeutic drug target[1][6][7]. **Key rationale and clarifications**: - This target is a *pseudogene*, not a functional RNA, receptor, enzyme, or other protein; therefore, it is not considered a therapeutic target[1][6][7]. - There is no evidence in available resources describing any biological function, disease association, or pharmacological relevance for RNU7-47P specifically[1][6][7]. - Pseudogenes like this may share sequence similarity with functional genes (such as RNU7-1 for U7 snRNA) but are generally transcriptionally inactive and biologically inert[1][6][7]. - "U7 small nuclear RNA" (also known as RNU7-1) is functionally important and involved in histone pre-mRNA processing, but RNU7-47P is not; it is a non-coding, non-functional genomic element[2][3][4][5]. If you are seeking information on the *functional* U7 snRNA or its gene (RNU7-1), that is a distinct and biologically relevant target involved in mRNA processing[2][3][4][5]. The entry above applies strictly to the RNU7-47P pseudogene.

Other names

U7.47U7.47 pseudogeneRNA, small nuclear U7.47 pseudogeneRNU7-47P