RNA, U7 small nuclear 90 pseudogene (RNU7-90P)

RNA, U7 small nuclear 90 pseudogene (RNU7-90P) refers to a **pseudogene** related to the functional U7 small nuclear RNA (U7 snRNA) genes. U7 snRNA itself is a highly conserved, short non-coding RNA (snRNA) that forms a core part of the U7 small nuclear ribonucleoprotein (snRNP) complex, which is essential for the processing of replication-dependent histone pre-mRNAs in metazoans[1][3][5]. The U7 snRNP specifically recognizes the histone downstream element (HDE) and is crucial for histone mRNA 3’ end processing, which is necessary for proper cell cycle progression and DNA replication[1][2][3][4]. Mutations affecting the main U7-encoding gene (such as RNU7-1) have been linked to disease, notably Aicardi-Goutières syndrome, due to disrupted histone pre-mRNA processing and inappropriate immune activation[4][6]. However, RNU7-90P itself is a **pseudogene**—meaning it does not code for a functional RNA and is not known to have biological function, disease association, or therapeutic relevance. **Analysis and Notes:** - **RNU7-90P** is a pseudogene and not a functional gene or protein; it is not a recognized therapeutic target, receptor, enzyme, or druggable entity[5]. - The functional, canonical gene in this family is **RNA, U7 small nuclear 1** (RNU7-1), not RNU7-90P[4][6]. - There is no evidence that RNU7-90P acts as a biomarker, has safety concerns, or is involved in human disease or therapy. - Information about biological function, disease relevance, drug interactions, etc., only applies to the active U7 snRNA genes—not to pseudogenes like RNU7-90P. **Conclusion:** RNU7-90P is a **pseudogene** and not a functional biological, pharmacological, or therapeutic target. Entries related to receptors, enzymes, or clinical biomarkers do not apply. Any role in biology or disease is through its similarity to U7 snRNA, not through direct activity[5].

Other names

RNU7-90PU7 small nuclear RNA pseudogene 90