RNA, variant U1 small nuclear 1 (RNVU1-1)

**RNA, variant U1 small nuclear 1** (RNVU1-1), also known as vU1.1 or by several similar aliases, is a member of the U1 small nuclear RNA gene family, composed of functional variants and pseudogenes. U1 snRNAs are essential components of the spliceosome complex responsible for recognizing 5' splice sites in pre-mRNA and facilitating splicing. Variant U1 snRNAs (vU1s) are transcribed, processed and can be assembled into snRNPs, but often differ in sequence from the canonical U1 snRNA. Most vU1s, including RNVU1-1, are expressed at much lower levels than canonical U1 snRNA and may have altered or limited capacity to facilitate normal splicing, with some variants having specific or minimal activity[1]. vU1s may also regulate alternative splicing and polyadenylation, protect nascent transcripts from premature cleavage, and modulate gene expression, particularly during developmental stages or in pluripotent stem cells[2]. Imbalances in the expression of U1/vU1 ratios have been linked to neurological diseases, including spinal muscular atrophy. RNVU1-1 is not a receptor, enzyme, transporter, or traditional therapeutic target; it is a noncoding RNA acting in RNA processing and gene expression regulation[1][2].

Other names

vU1.1U1P14U1.4vU1.10RNU1-53RNU1-10PRNU1P10RNVU1-10RNA, variant U1 small nuclear 10