RNA, variant U1 small nuclear 14 (RNVU1-14)

RNA, variant U1 small nuclear 14 (RNVU1-14) is a member of the variant U1 small nuclear RNAs, a class of short, non-coding RNAs essential for the splicing of pre-mRNA in the major spliceosome[2][1]. Like canonical U1 snRNA, RNVU1-14 recognizes 5' splice sites via base-pairing and plays a critical role in ensuring precise splicing of many genes[1]. RNVU1-14 is part of a family of highly similar variant U1 snRNA genes with complex genomic organization and extensive sequence redundancy, making its analysis and functional dissection technically challenging[1]. Mutations in U1 and its variants, including RNVU1-14, have been implicated in various malignancies due to their effect on global splicing fidelity, leading to widespread aberrant splicing in tumor suppressors and oncogenes[1]. The precise pathogenic contribution of RNVU1-14 relative to other U1 snRNA genes is unclear, but mutations across this gene family are associated with worse outcomes in some cancers[1]. RNVU1-14 is not a protein, enzyme, receptor, or traditional druggable target, but is increasingly recognized for its fundamental regulatory role in RNA biology, with clinical interest as a diagnostic or prognostic biomarker[1][2].

Other names

vU1.14RNU1-37RNVU1-14