RNA, variant U1 small nuclear 18 (RNVU1-18)

RNA, variant U1 small nuclear 18 (RNVU1-18) is a variant form of the small nuclear RNA (snRNA) U1, belonging to a family of highly homologous noncoding RNAs involved in the major spliceosome complex. Like canonical U1 snRNA, its primary biological function is the recognition of pre-mRNA 5' splice sites through base-pairing, a crucial step in the splicing of precursor mRNA transcripts. RNVU1-18 is annotated as a variant rather than canonical U1 snRNA gene and is found at the 1q21 chromosomal locus, often within segmental duplication regions, contributing to high interindividual structural variation and complex genomic architecture[2]. Mutations in RNVU1-18 and related U1 snRNAs have been observed recurrently in certain malignancies, most notably medulloblastoma and CLL, where they induce widespread aberrant RNA splicing and are associated with poorer prognosis. These mutations can disrupt correct splicing of critical oncogenes and tumor suppressors, and detection of such alterations is important for cancer diagnostics and prognostics. Despite its roles in splicing regulation and disease, RNVU1-18 is not a protein, receptor, enzyme, or druggable therapeutic target, but rather a noncoding RNA product critical to RNA processing[2][1][5].

Other names

vU1.18U1P101U1P15U1.15RNU1-25RNU1-25PRNU1-5RNU1P1RNU1P9RNA, U1 small nuclear 25, pseudogeneRNA, U1 small nuclear 5RNA, U1 small nuclear pseudogene 1RNA, U1 small nuclear pseudogene 9