RNA, variant U1 small nuclear 19 (RNVU1-19)

RNA, variant U1 small nuclear 19 (RNVU1-19), also referred to as vU1.19 and by several related names, is a member of the variant U1 small nuclear RNAs. U1 snRNA is a noncoding RNA essential for the function of the spliceosome, the molecular complex responsible for the removal of introns from pre-mRNAs. The U1 snRNA gene family includes numerous variant genes (vU1s) such as vU1.19, which are expressed at much lower levels than the canonical U1 snRNA. These variants are transcribed, capped, and incorporated into small nuclear ribonucleoprotein complexes (snRNPs), and vU1.19 can be found in spliceosomes. Unlike canonical U1, vU1.19 has not demonstrated the ability to support pre-mRNA splicing in reconstituted assays. vU1 family members may have cell type-specific expression patterns and have been implicated in stem cell biology and possible disease modulation through altered ratios with canonical U1 snRNA. However, there1 is currently no evidence that vU1.19 is a stand-alone therapeutic target, nor are there any known drugs or biomarkers specifically interacting with or detecting this variant[1][2].

Other names

vU1.19RNU1-126vU1.13RNU1-147RNVU1-13RNA, variant U1 small nuclear 13