Target intelligence / Profile preview

RNA, variant U1 small nuclear 29 (RNVU1-29)

Target: RNVU1-29
Molecular classification: Small nuclear RNA (snRNA), Non-coding RNA, U1 snRNA family (variant type)

Overview

RNA, variant U1 small nuclear 29 (RNVU1-29), also known as LOC124904613, is a variant U1 small nuclear RNA (snRNA) gene in the human genome that belongs to the snRNA class and is involved in RNA splicing.

Other names: LOC124904613RNVU1-29

Mechanism of action

Not applicable. As no drugs are known to specifically target this RNA, there are no documented mechanisms of action.

Biological functions

Pre-mRNA splicing5′ splice site recognitionComponent of U1 small nuclear ribonucleoprotein (snRNP)

Disease associations

Possible involvement in cancer (by analogy with other U1 and variant U1 snRNAs, which harbor hot-spot mutations implicated in medulloblastoma, chronic lymphocytic leukemia, and hepatocellular carcinoma)Potential impact on splicing of oncogenes and tumor suppressors

Biomarkers

Mutations in the broader U1 sn

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