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RNA 5'-phosphate and 3'-OH ligase 1 (RLIG1)
- Target
- RLIG1
- Molecular classification
- Enzyme, RNA ligase (ATP-dependent), ATP-grasp superfamily enzyme
01
Overview
RNA 5'-phosphate and 3'-OH ligase 1 (RLIG1) is an ATP-dependent enzyme that catalyzes the ligation of RNA strands containing a 5'-phosphate and a 3'-hydroxyl group, via a three-step nucleotidyl transfer mechanism involving an enzyme-AMP intermediate. RLIG1 is selective for single-stranded RNA substrates, does not seal nicks in DNA-RNA hybrids, and may play a role in RNA repair and integrity, particularly during oxidative stress. Genetic evidence and biochemical studies implicate RLIG1 in tRNA metabolism, especially in the brain, with potential, though not well-characterized, links to human disease[1][2][5].
- Other names
- C12orf29RNA ligase 1RnlDKFZp434N2030uncharacterized protein C12orf29
02
Biological functions
RNA ligation (joining RNA molecules with 5'-phosphate and 3'-hydroxyl termini)Maintenance of RNA integrityResponse to reactive oxygen speciestRNA ligation and possible involvement in tRNA biology
03
Disease associations
Other (no direct strong evidence for major roles in cancer, infection, etc., but mutations annotated in rare genetic disorders such as Leber congenital amaurosis 10 and Bardet-Biedl syndrome 14)
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