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RNA-binding motif protein, X-linked-like 3 (RBMXL3)
- Target
- RBMXL3
- Molecular classification
- RNA-binding protein, Other
01
Overview
RNA-binding motif protein, X-linked-like 3 (RBMXL3) is a primate-specific RNA-binding protein that contains an RNA recognition motif. It is involved in binding mRNA and snRNA, participating in mRNA splicing through the spliceosome, and modulating mRNA stability. A key identified function is the dexamethasone-inducible stabilization of human surfactant protein B (SP-B) mRNA in lung epithelial cells by binding to a specific 30-nucleotide hairpin element in the 3′-UTR, thereby influencing the pulmonary surfactant system. The gene shows some predicted involvement in sex reversal syndromes but has not been established as a classic therapeutic target or drug receptor[1][5][7][6][2][3].
- Other names
- CXorf55FLJ40249RMXL3_HUMANRNA binding motif protein, X-linked like 3
02
Biological functions
mRNA bindingsnRNA bindingmRNA splicing via spliceosomeRegulation of mRNA stability (notably for surfactant protein B mRNA)
03
Disease associations
46,Xy Sex Reversal 3Other (no strong disease association beyond rare syndromes)
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