RNA-directed RNA Polymerase (Hepatitis C Virus) (NS5B)

The RNA-directed RNA polymerase (NS5B) of the Hepatitis C virus (HCV) is a viral enzyme essential for the replication of the HCV genome. It catalyzes the synthesis of new viral RNA strands using an existing RNA template, a process central to the virus's life cycle and infectivity. As an essential component in HCV replication, NS5B is a prime target for antiviral drug development. Inhibitors include nucleoside analogs, non-nucleoside inhibitors, and natural compounds like quercetagetin.

Other names

HCV RNA-dependent RNA polymeraseNS5B protein

Inhibition of viral RNA replication through various mechanisms, including chain termination, allosteric inhibition, and template binding interference.