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Target intelligence / Profile preview
RNA polymerase II, I and III subunit K (POLR2K)
- Target
- POLR2K
- Molecular classification
- Enzyme (DNA-directed RNA polymerase subunit), Transcription factor (as a subunit of eukaryotic RNA polymerases)
01
Overview
RNA polymerase II, I and III subunit K (POLR2K) is one of the smallest core subunits shared by all three major eukaryotic DNA-directed RNA polymerases (I, II, and III), which are essential for synthesizing messenger RNA, ribosomal RNA precursors, and many functional non-coding RNAs[2][4][1][5]. POLR2K does not act as an independent enzyme or receptor but is instead a ubiquitous, indispensable subunit of the multi-protein RNA polymerase complexes required for transcription of nuclear genes in eukaryotic cells. Pathogenic variants may cause severe syndromic disorders, though direct pharmacological targeting is not currently considered tractable due to the essential nature of the subunit[2][4].
- Other names
- DNA-directed RNA polymerases I, II, and III subunit RPABC4RNA polymerases I, II, and III subunit ABC4RNA polymerase II subunit KPolymerase (RNA) II (DNA directed) polypeptide KRNA polymerase II 7.0 kDa subunitRPB10alphaRPB12ABC10-alphahRPB7.0hsRPB10aMafYMt1aRPABC4RPB7.0
02
Biological functions
Transcription (catalyzes DNA to RNA synthesis)Regulation of gene expressionSynthesis of mRNA, rRNA precursors, and functional non-coding RNAs
03
Disease associations
ImmunodeficiencyPrimary ciliary dyskinesiaOther (limited evidence of further direct disease roles, primarily implicated through general defects in transcription machinery)
04
Safety considerations
Essentiality: As a core subunit required for all three RNA polymerases, inhibition is likely to have severe, non-selective toxicity linked to loss of global transcription[2][4].
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