RNA polymerase II, I and III subunit L (POLR2L)

RNA polymerase II, I and III subunit L (POLR2L) is a highly conserved protein subunit shared by the three major nuclear DNA-dependent RNA polymerases (I, II, and III), which catalyze the transcription of DNA into various classes of RNA, including messenger RNA (mRNA), ribosomal RNA (rRNA), and several small non-coding RNAs. The POLR2L protein is characterized by four conserved cysteines forming an atypical zinc-binding domain. As a core component, it plays a structural and functional role in the assembly, stability, and activity of the multi-subunit RNA polymerase complexes essential for gene expression in all eukaryotic cells. Mutations in POLR2L have been associated with rare hereditary diseases such as Cockayne syndrome and Hyperparathyroidism 2 with jaw tumors[1][2][7][9]. No drugs are known to specifically target this subunit due to its fundamental and ubiquitous role in cell survival.

Other names

DNA-directed RNA polymerases I, II, and III subunit RPABC5DNA-directed RNA polymerase III subunit LRNA polymerase II 7.6 kDa subunitRPB10RPB10betaRPB7.6hRPB7.6hsRPB10bRPABC5RBP10polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDapolymerase (RNA) II subunit LHRPB7.6HSRPB10B