Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Rotavirus Spike Protein VP4 Distal Domain VP8* (VP8*)
- Target
- VP8*
- Molecular classification
- Viral protein, Attachment protein, Glycan-binding protein
01
Overview
The VP8* domain is the distal portion of the rotavirus (RV) outer capsid spike protein VP4. It plays a crucial role in the initial attachment of rotavirus to host cells by binding to specific cellular receptors, thereby facilitating viral entry and infection. The interaction specificity of VP8* with host cell surface glycans determines host range, tissue tropism, and cross-species transmission. VP8* has a galectin-like fold. In some animal RVs, VP8* binds sialic acid-containing glycans, while human RVs often bind histo-blood group antigens (HBGAs). Variations in glycan-binding pockets underlie differences in species susceptibility, impacting zoonotic potential. Without functional engagement between VP8* and its target receptor(s), rotavirus cannot efficiently attach or enter host cells.
- Other names
- VP8VP4 distal domainRotavirus attachment protein VP8*RV VP8*
02
Biological functions
Viral attachment to host cellsReceptor bindingMediating viral entryHost cell recognitionDetermination of host rangeInitiation of infection
03
Disease associations
Rotavirus infectionGastroenteritisDiarrheaViral pathogenesisZoonotic transmission
04
Safety considerations
Potential for immune evasion through glycan binding site mutationsVariability in glycan binding across rotavirus strainsRisk of zoonotic transmission and emergence of new strains
Beyond the preview
Go deeper on Rotavirus Spike Protein VP4 Distal Domain VP8* (VP8*).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Rotavirus Spike Protein VP4 Distal Domain VP8* (VP8*).