Rotavirus VP8* Protein (VP8*)

The rotavirus VP8* protein is a domain located at the distal end of the viral spike protein VP4. It plays a critical role in mediating the initial attachment of rotaviruses to host cells by binding to specific cell surface glycans, which facilitates viral entry and infection. The receptor specificity of VP8* varies among rotavirus strains, with animal rotaviruses often binding terminal sialic acid residues and human rotaviruses interacting with histo-blood group antigens (HBGAs). This interaction influences host range, tissue tropism, and susceptibility to infection. VP8* is a key target for neutralizing antibodies and vaccine development.

Other names

VP8 starRotavirus VP4 spike protein VP8* domain

Antibodies targeting VP8* can block virus-cell attachment, neutralizing viral infectivity.