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Target intelligence / Profile preview
RPA1 related single stranded DNA binding protein, X-linked (RADX)
- Target
- RADX
- Molecular classification
- Other (single-stranded DNA-binding protein)
01
Overview
RPA1 related single stranded DNA binding protein, X-linked (RADX) is a nuclear, single-stranded DNA-binding protein recruited to replication forks where it plays a critical role in the maintenance of genome stability by antagonizing the accumulation of RAD51 to prevent excessive homologous recombination. RADX’s function is essential for balancing fork remodeling and protection, minimizing the risk of replication fork collapse, but it does so without inhibiting the cell’s capacity to complete homologous recombination when repair of double-strand breaks is necessary. Mutations in RADX are associated with rare diseases including Mirror Movements 1 and Schimke immunoosseous dysplasia. It is not generally considered a therapeutic target such as a receptor, channel, or enzyme.
- Other names
- RADXCXorf57FLJ10178FLJ14191RPA-related and RAD51-antagonist, X-chromosomeRPA-related protein RADXRPA1 related single stranded DNA binding proteinuncharacterized protein CXorf57RADX_HUMAN
02
Biological functions
Single-stranded DNA bindingNegative regulation of double-strand break repair via homologous recombinationMaintenance of genome stabilityAntagonism of RAD51 at replication forks
03
Disease associations
Other (implicated in rare developmental/neurological diseases such as Mirror Movements 1 and Schimke immunoosseous dysplasia)
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