RTEL1-TNFRSF6B readthrough (non-protein coding) (RTEL1-TNFRSF6B)

RTEL1-TNFRSF6B is a naturally occurring readthrough RNA transcript formed between the RTEL1 and TNFRSF6B genes on chromosome 20. It is classified as a long noncoding RNA (lncRNA) and is believed to be targeted by nonsense-mediated decay, making it unlikely to encode a protein. Instead, RTEL1-TNFRSF6B likely functions in the regulation of gene expression at the RNA level, potentially acting through interactions with RNA binding proteins (such as DKC1, DHX9, AIFM1, DICER1, ADAR, ACIN1, DDX54) and microRNAs (notably several miRNAs involved in neurological and developmental processes). The transcript has been linked to dysregulation in conditions like epilepsy and telomere biology disorders, primarily via its effects on gene regulatory networks and chromatin dynamics, but is not a conventional therapeutic target, receptor, enzyme, transporter, or protein of direct pharmacological interest[1][2][3][4]. RTEL1-TNFRSF6B is thus best understood as a regulatory, non-protein-coding *transcript* with potential disease-association via gene expression dysregulation, rather than as a direct molecular target for drug development.

Other names

RTEL1-TNFRSF6B readthrough (NMD candidate)RTEL1-TNFRSF6B readthrough (non-protein coding)