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Target intelligence / Profile preview
S-adenosylmethionine (SAM)-dependent Methyltransferase (SAM-MT)
- Target
- SAM-MT
- Molecular classification
- Enzyme, Methyltransferase
01
Overview
S-adenosylmethionine (SAM)-dependent methyltransferases are a family of enzymes that utilize SAM as a cofactor to transfer a methyl group to a variety of substrates, including DNA, RNA, proteins, lipids, and small molecules. This methylation process is crucial for a wide range of biological functions, including epigenetic regulation, biosynthesis, and detoxification. Aberrant activity of these enzymes is implicated in various diseases.
- Other names
- S-Adenosylmethionine MethyltransferaseSAM MethyltransferaseAdoMet MethyltransferaseSAM-dependent methyltransferase
02
Mechanism of action
Inhibition of methyl group transfer
03
Biological functions
Methyl group transferEpigenetic regulationNucleic acid modificationProtein modificationLipid modificationSmall molecule modificationPolyamine synthesisTranssulfuration pathwayDetoxification
04
Disease associations
Liver diseaseNeuropsychiatric disordersCancerMetabolic disorders
05
Safety considerations
Altered epigenetic statesMetabolic disorders
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