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Target intelligence / Profile preview
Salmonella enterica serovar Typhi Capsular Polysaccharide (Vi Antigen) (Vi Antigen)
- Target
- Vi Antigen
- Molecular classification
- Polysaccharide, Capsular polysaccharide, Virulence factor
01
Overview
The Vi antigen is a capsular polysaccharide expressed on the surface of *Salmonella enterica* serovar Typhi, the causative agent of typhoid fever. This capsule is a key virulence factor that distinguishes S. Typhi from most other Salmonella serovars. It inhibits phagocytosis and reduces immune recognition, contributing to the bacterium's ability to cause infection. The purified Vi capsular polysaccharide is used in typhoid vaccines to induce protective antibodies.
- Other names
- Vi capsular polysaccharideVi polysaccharideVi antigen
02
Mechanism of action
Induction of anti-Vi antibodies that promote complement-mediated killing of Salmonella Typhi
03
Biological functions
Immune evasionAnti-phagocytosisAdhesionComplement inhibitionModulation of inflammation
04
Disease associations
Typhoid feverSalmonella infection
05
Safety considerations
Limited efficacy in young children (Vi polysaccharide vaccines)Potential for reduced immunogenicity in some individualsRare cases of injection site reactions
06
Interacting drugs
Typhoid vaccines (Vi polysaccharide vaccines)
1 more in the full profile.
07
Biomarkers
Anti-Vi antibody titers (vaccine efficacy)Vi antigen detection (diagnosis of infection)
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