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Target intelligence / Profile preview
Salmonella enterica serovar Typhi Capsular Polysaccharide Antigen (Vi) (Vi antigen)
- Target
- Vi antigen
- Molecular classification
- Polysaccharide, Capsular antigen
01
Overview
The Vi antigen is a capsular polysaccharide found on the surface of *Salmonella enterica* serovar Typhi, the bacterium responsible for typhoid fever. This capsule is a key virulence factor that confers resistance to complement-mediated killing and phagocytosis. Vaccines based on the Vi polysaccharide are effective at preventing typhoid fever by inducing protective antibody responses.
- Other names
- Vi capsular polysaccharideVi antigenVi polysaccharide
02
Mechanism of action
N/A
03
Biological functions
Immune evasionAdhesionAntiphagocytosisComplement resistanceModulation of inflammatory response
04
Disease associations
Typhoid feverInfection
05
Safety considerations
Genetic instability leading to loss of expressionPotential for Vi-negative strains to cause disease
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