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Target intelligence / Profile preview
Salmonella Typhi Capsular Polysaccharide (Vi Antigen) (Vi Antigen)
- Target
- Vi Antigen
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
The Vi antigen is a capsular polysaccharide found on the surface of *Salmonella enterica* serovar Typhi. It is a linear homopolymer composed of α-1,4-linked N-acetylgalactosaminuronic acid residues, variably O-acetylated at the C-3 position. The Vi antigen is a key virulence factor involved in immune evasion by inhibiting complement deposition and phagocytosis. It interacts with host receptors like DC-SIGN on macrophages, facilitating uptake and potentially promoting systemic infection. It is the basis for subunit vaccines against typhoid fever, inducing protective antibody responses.
- Other names
- Vi polysaccharideVi capsuleCapsular polysaccharide of Salmonella Typhi
02
Mechanism of action
N/A
03
Biological functions
Immune evasionInhibition of complement activationInhibition of phagocytosisAdherenceInteraction with host receptors (DC-SIGN)
04
Disease associations
Typhoid feverSalmonella infectionBacterial pathogenesis
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