Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
SAP30L antisense RNA 1 (head to head) (SAP30L-AS1)
- Target
- SAP30L-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
SAP30L antisense RNA 1 (head to head) (abbreviated as SAP30L-AS1) is a long non-coding RNA gene located on human chromosome 5. It is classified as an antisense RNA, meaning it is transcribed from the DNA strand opposite to the protein-coding SAP30L gene[4][5][6][7]. SAP30L-AS1 physically binds the promoter region of the neighboring SAP30L gene, repressing its expression. In prostate cancer, SAP30L-AS1 expression is upregulated, and promotes tumor growth by enhancing cell proliferation and inhibiting apoptosis in cancer cells. Conversely, knockdown of SAP30L-AS1 suppresses cancer proliferation and induces apoptosis[2]. Higher levels of SAP30L-AS1 correlate with more advanced disease and poorer prognosis. It is being explored as a potential target for cancer therapy, as well as a prognostic biomarker for patient stratification in prostate cancer[2][4]. No drugs currently target SAP30L-AS1 directly, and its use as a therapeutic target remains investigational.
- Other names
- GALNT10-AS1GALNT10 antisense RNA 1FLJ38109CTB-157D17.1SAP30L-AS1 (head to head)
02
Biological functions
Negative regulation of SAP30L gene expressionPromotion of cell proliferationInhibition of apoptosisRegulation of gene expression in cancer cells
03
Disease associations
Cancer (specifically prostate cancer)
04
Biomarkers
Potential prognostic biomarker for prostate cancer progression
Beyond the preview
Go deeper on SAP30L antisense RNA 1 (head to head) (SAP30L-AS1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on SAP30L antisense RNA 1 (head to head) (SAP30L-AS1).