Sarcosine dehydrogenase, mitochondrial (SARDH)

Sarcosine dehydrogenase, mitochondrial (SARDH), is a flavoprotein oxidoreductase enzyme found in the mitochondrial matrix, encoded by the human SARDH gene. It catalyzes the oxidative demethylation of sarcosine (N-methylglycine) to glycine, producing formaldehyde and coupling to the electron-transferring flavoprotein for redox chain participation. The enzyme plays a central role in sarcosine and choline metabolism and contributes to cellular one-carbon metabolism via tetrahydrofolate-dependent processes. Mutations in SARDH cause sarcosinemia, a rare autosomal recessive metabolic disorder. Elevated sarcosine and SARDH dysfunction are under investigation for roles in prostate cancer. While SARDH presents as a plausible metabolic enzyme target, there are currently no clinical drugs that act on it directly

Other names

SARDHDMGDHL1SarDHSDHBPR-2SARSARDSarcosine dehydrogenaseMonomethylglycine dehydrogenaseSarcosine N-demethylase

For methoxyacetic acid, competitive inhibition of sarcosine dehydrogenase by occupying the enzyme’s active site and preventing sarcosine binding. For theoretical cancer therapy, hypothetical inhibition could alter sarcosine metabolism and affect metastatic potential.