Scaffold protein (cell migration)

The term "cell migration scaffold/supporter" refers to various scaffold proteins that spatially and functionally organize protein complexes required for cell movement. Scaffold proteins such as ERC1/ELKS, liprin-α1, BPGAP1, RACK1, and tetraspanins localize near the plasma membrane, regulating cytoskeletal assembly, adhesion turnover, and signaling cascade specificity during cell migration. These proteins are essential for tissue development, immune surveillance, wound healing, and contribute to pathological processes such as tumor metastasis and inflammatory disease progression. Scaffold proteins are typically not direct therapeutic targets, but modulating their associated networks may influence disease outcomes

Other names

Scaffolding proteinmolecular scaffold (cell migration)cytoskeletal scaffold (context-dependent)

Scaffold proteins do not have a single mechanism of action; they assemble protein complexes, modulate spatial/temporal signaling cascades, and coordinate cytoskeletal dynamics to promote or restrain cell migration