Scavenger receptor class B type I, ATP-binding cassette transporter A1, ATP-binding cassette transporter G1 (SR-BI, ABCA1, ABCG1)

The major macrophage membrane-associated HDL receptors are Scavenger receptor class B type I (SR-BI), ATP-binding cassette transporter A1 (ABCA1), and ATP-binding cassette transporter G1 (ABCG1). These proteins localize to the plasma membrane of macrophages and facilitate the efflux and transfer of cholesterol and phospholipids to HDL particles in the extracellular space, thereby regulating cholesterol homeostasis and contributing to reverse cholesterol transport. Dysfunction of these receptors in macrophages leads to lipid accumulation, foam cell formation, and increased risk of atherosclerosis. These proteins are considered important therapeutic targets for modulating cardiovascular and metabolic disease risk[3][4]. Note: The queried name is not a single molecule but refers collectively to several functionally related surface proteins on macrophages, with SR-BI, ABCA1, and ABCG1 being the principal and best-validated HDL-interacting molecules in this context[3]. If you are seeking structured information for a singular, canonical target, it is best to specify one of these (for example, "Scavenger receptor class B type I" (SR-BI)), as each has distinct properties and clinical significance[2][3][4].

Other names

HDL receptorHDL binding receptorcholesterol efflux transporter

Facilitation or inhibition of cholesterol and phospholipid transfer between macrophage membranes and HDL, modulating cholesterol balance