Schistosoma mansoni calpain large subunit (Sm-p80) (Sm-p80)

Sm-p80 is the 80 kDa large subunit of the calcium-activated neutral protease (calpain) expressed by the parasitic flatworm Schistosoma mansoni [1, 3]. It is a surface-associated protein that plays a pivotal role in the biogenesis and continuous renewal of the parasite's tegument, which serves as a primary defense mechanism against the host's immune system [2, 4]. By facilitating membrane recycling, Sm-p80 allows the parasite to evade immune detection and survive within the host's bloodstream for years [1, 7]. Sm-p80 is a premier vaccine candidate for schistosomiasis, a neglected tropical disease affecting hundreds of millions of people [2, 6]. Experimental vaccines, such as SchistoShield, utilize recombinant Sm-p80 to induce protective antibodies and T-cell responses that disrupt the parasite's membrane integrity and reduce egg production [3, 8]. Preclinical studies in non-human primates have demonstrated that Sm-p80-based vaccines can significantly reduce worm burden, tissue egg retention, and parasite transmission [7, 13]. Human clinical trials are currently evaluating its safety and immunogenicity to address the global burden of this neglected tropical disease [3, 8]. Unlike current treatments like praziquantel, which target adult worms, Sm-p80-based interventions aim to provide long-term immunity and block transmission [2, 4].

Other names

Sm-p80 antigenSchistosoma mansoni calpain 80 kDa subunitCalpain large subunitSm-p80 calpain

Induction of host immune responses (antibodies and T-cells) that target the Sm-p80 protein on the parasite surface, disrupting tegument renewal and leading to parasite death and reduced fecundity.