SEC16 homolog B, endoplasmic reticulum export factor (SEC16B)

SEC16 homolog B, endoplasmic reticulum export factor (SEC16B), is a scaffold protein involved in defining and organizing endoplasmic reticulum exit sites (ERES) for COPII vesicle formation, which mediate selective transport of proteins and lipids from the ER to the Golgi apparatus. SEC16B also has a specialized, non-redundant role in peroxisome biogenesis by regulating the export of biogenesis factors like PEX3 and PEX16 from the ER to peroxisomes. It is distinct from its longer paralog SEC16A and is considered a minor or specialized isoform in mammals. Mutations in SEC16B can result in defective ER export and are associated with certain disease phenotypes including impaired collagen trafficking, osteogenesis imperfecta, cone-rod dystrophy 2, and associations with body mass index. **Notes:** - SEC16B is an essential trafficking protein but not a canonical drug target (such as a receptor, enzyme, or transporter) and is not known to be the direct target of any marketed drug. - No approved drugs, mechanisms of action for drugs, or biomarker applications have been established for SEC16B. - Disruption of SEC16B function can lead to severity in processes that depend on protein or organelle trafficking, but therapeutic targeting/safety concerns are not established due to lack of direct targeting.

Other names

Protein transport protein Sec16BKIAA1928LZTR2RGPRSEC16SRGPR-p117PGPR-p117Sec16SLeucine zipper transcription regulator 2Regucalcin gene promoter region-related protein p117regucalcin gene promotor region related protein